Study Supporting Herd-wide Reduction in Incidence and Severity of Diarrhea with Prophylactic Use of Neonorm Calf  Published in Journal of Dairy Science

Study Supporting Herd-wide Reduction in Incidence and Severity of Diarrhea with Prophylactic Use of Neonorm Calf Published in Journal of Dairy Science

Study Conducted in Association with Cornell University College of Veterinary Medicine and Demonstrates Significant Benefits

As announced on February 14, 2017, the publication of a study titled “Prophylactic use of a standardized botanical extract for the prevention of naturally occurring diarrhea in newborn Holstein calves” in the official journal of the American Dairy Science Association, Journal of Dairy Science—a leading peer-reviewed general dairy research journal. The study was conducted by researchers from Cornell University College of Veterinary Medicine.

Neonorm Calf, one of Jaguar’s lead non-prescription products, has been formulated and clinically tested to help proactively retain fluid in dairy calves and reduce the severity of diarrhea—aiding the animals in avoiding debilitating, dangerous levels of dehydration associated with scours. The powder form of the product allows for ease of administration for herd-wide management.

The objectives of this study were to evaluate the prophylactic use of SB-300, the standardized botanical extract in Neonorm Calf, on reducing fecal water loss and diarrhea events in Holstein bull calves individually housed under a restricted whole-milk feeding regimen (6 liters/day) from 1 to 25 days of life.

A double-blinded randomized clinical trial was designed to allocate a total of 40 newborn calves into 1 of 2 treatment groups: 20 calves received (twice daily) a solution containing 500 mg of SB-300 added to whole milk for the first 15 days of life, and the other 20 calves received sterile water added to whole milk for the same period. Treatment solutions had a total volume of 10 mL per treatment. Data regarding fecal dry matter were collected to precisely measure water content in fecal samples and to define diarrhea events.

The group treated with SB-300 had significantly increased fecal dry matter during the study period compared with calves in the control group. Additionally, significantly fewer events of diarrhea were observed for calves in the group treated with SB-300 (16.9%) compared with calves in the control group (46.5%). Dehydration status was evaluated and treated accordingly; calves with moderate dehydration were offered oral electrolytes, and calves with severe dehydration were rescued with intravenous fluid therapy. Calves in the SB-300 group had fewer intravenous fluid therapies administered during the study period (1.6%) compared with the control group (3.1%). Overall fluid therapy administered (oral electrolytes plus intravenous fluids) was significantly higher for the control group (9.2%) compared with the SB-300 group (6.1%) during the study period.

“These results suggest that 500 mg of SB-300 added to the milk for 15 days can reduce the incidence of diarrhea and reduce severe dehydration in milk-fed calves,” stated Dr. Andre Gustavo Teixeira of Cornell, the principal investigator of the study. “The results appear to support the potential prophylactic benefits of an easy-to-administer powder formulation of Neonorm Calf on reducing the incidence and severity of diarrhea and associated fluid therapy in calves.”

The study results complement the results of a prior study, also conducted by Jaguar in association with Cornell, that evaluated the effect of Neonorm Calf on diarrhea severity and consistency in newborn Holstein bull calves experiencing diarrhea induced by enterotoxigenic Escherichia coli (E. coli). The results of this earlier study were published in Journal of Dairy Science in 2015.

Additionally, the positive prophylactic effect of the powder formulation of Neonorm in calves supports and underscores the prophylaxis data generated by the piglet studies of the powder formulation of Neonorm conducted in 2016 in China by Chinese investigators. As the most common disease in newborn pigs1, diarrhea has a significant impact on the global swine market as well as food security. As Jaguar announced in September 2016, the Company has signed an exclusive supply and distribution agreement for Croton lechleri botanical extract with Fresno, California-based Integrated Animal Nutrition and Health Inc. for dairy cattle and pigs in the Chinese marketplace.

“The standardized botanical extract in Neonorm Calf is sustainably derived from the Amazonian tree species, Croton lechleri, and has a rich history of medicinal use by indigenous peoples in the Northwestern Amazon rainforests of South America,” commented Dr. Steven King, Jaguar’s Executive Vice President of Sustainable Supply, Ethnobotanical Research and IP. “In recognition of this, the study recently published in Journal of Dairy Science acknowledges the ethnomedical expertise of the indigenous peoples of the Northwestern Amazon region who discovered how to use the latex of Croton lechleri for the treatment of diarrhea and other gastrointestinal conditions.”

Neonatal calf diarrhea is a multifactorial disease that can be caused by infectious and noninfectious factors. In a report from the United States Department of Agriculture’s 2010 National Animal Health Monitoring System study, diarrhea was the most common disorder affecting preweaned dairy heifers, with a nationwide incidence of almost 19%, and was the leading cause of death in preweaned heifers.

To read Jaguar’s press release about this news, click here.

1Diarrhoea or Scour. Retrieved July 24, 2016.